Mississippi's 4th congressional district covers the southeastern region of the state. It includes all of Mississippi's Gulf Coast, stretching ninety miles between the Alabama border to the east and the Louisiana border to the west, and extends north into the Pine Belt region. It includes three of Mississippi's four most heavily populated cities: Gulfport, Biloxi, and Hattiesburg. Other major cities within the district include Bay St. Louis, Laurel, and Pascagoula.
The district is home to a wealth of military installments including: Keesler Air Force Base, Camp Shelby Joint Forces Training Center, the Gulfport Construction Battalion Center, and the Mississippi Air National Guard's Combat Readiness Training Center. It is also home to the University of Southern Mississippi and Stennis Space Center, among other things.